Police and protesters threw stones at each other on a main road outside Tahrir, near the American and British embassies, they told sources.
They said police also fired birdshot at protesters, wounding at least two people who were taken away by an ambulance.
Egypt has been gripped by unrest since rallies last week marking the second anniversary of the uprising that toppled President Hosni Mubarak.
The protests turned violent on Saturday after a Cairo court sentenced 21 residents of the canal city of Port Said to death for their involvement in football-related violence last year.
The health ministry said on Thursday two more people had died from their injuries following clashes, bringing to 56 the number of deaths nationwide in a week of violence.
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